DMDM Hydantoin, DMDMH, Cosmetic Preservative-CAS 6440-58-0

DMDM Hydantoin, DMDMH, Cosmetic Preservative-CAS 6440-58-0

DMDM Hydantoin, commonly known as DMDMH, is a widely used formaldehyde-releasing preservative effective against a broad spectrum of bacteria, yeast, and mold. With the INCI name DMDM HYDANTOIN and CAS number 6440-58-0, this hydantoin derivative works by slowly releasing small amounts of formaldehyde over time, creating an environment that inhibits microbial growth. It is available in both liquid form (typically 55% active solution) and powder form (≥99% active), offering formulation flexibility for various product types.

DMDM Hydantoin is valued for its excellent stability across a wide pH range (3.0–9.0) and its compatibility with most cosmetic ingredients including surfactants, proteins, and emulsifiers. Approved for use in both rinse-off and leave-on cosmetics at concentrations up to 0.6% in China and the EU, it is one of the most cost-effective and widely used preservatives in the cosmetic industry. While it releases formaldehyde, the levels are carefully controlled and well within safety limits when used as directed, comparable to formaldehyde levels naturally found in many fruits and foods.

Key Benefits

• Broad-spectrum antimicrobial: Effective against bacteria, yeast, and mold

• Long-lasting preservation: Slow formaldehyde release provides sustained protection

• Wide pH stability: Effective across pH 3.0–9.0, suitable for most formulations

• Excellent compatibility: Works with surfactants, proteins, emulsifiers and most ingredients

• Cost-effective: Economical price point with proven efficacy, widely available

• Globally approved: Meets China, EU, US FDA and major global regulatory standards

• Both rinse-off and leave-on: Suitable for all cosmetic product types

• Thermally stable: Withstands typical cosmetic manufacturing temperatures

• Easy to use: Water soluble, simple to incorporate into formulations

• Synergistic effects: Works well with other preservatives like IPBC for enhanced protection

Applications

• Shampoos and hair cleansers: Recommended usage 0.1%–0.4% active

• Hair conditioners and hair masks: Recommended usage 0.1%–0.3% active

• Body washes and shower gels: Recommended usage 0.1%–0.4% active

• Facial cleansers and face washes: Recommended usage 0.1%–0.3% active

• Face creams and lotions: Recommended usage 0.1%–0.4% active

• Serums and essences: Recommended usage 0.1%–0.3% active

• Toners and facial mists: Recommended usage 0.1%–0.3% active

• Facial masks and sheet masks: Recommended usage 0.1%–0.3% active

• Baby care products (lotions, shampoos): Recommended usage 0.1%–0.3% active

Sunscreens and sun care products: Recommended usage 0.1%–0.4% active

Certificate Of Analysis (COA)

Frequently Asked Questions (FAQ) 

Q1: What is the difference between liquid grade and powder grade DMDM Hydantoin?

A: Liquid grade DMDM Hydantoin is typically a 55% aqueous solution, which is easy to handle and add directly to the water phase of formulations. It is the most commonly used form in the cosmetic industry. Powder grade is ≥99% pure active, which is more concentrated and takes up less storage space but requires dissolution before use. Both forms have the same preservative efficacy when dosed correctly. Liquid grade is generally preferred for most cosmetic applications due to ease of handling.

Q2: How do I use DMDM Hydantoin in formulations? Are there any compatibility issues?

A: DMDM Hydantoin is typically added to the water phase of formulations and can be added at room temperature or during the heating phase (up to 80°C). It is stable across pH 3–9 and compatible with most cosmetic ingredients including surfactants, proteins, emulsifiers, and other preservatives. It is often combined with other preservatives like IPBC, phenoxyethanol, or ethylhexylglycerin for broader spectrum protection. It is generally compatible with proteins and does not cause protein denaturation like some other formaldehyde releasers. Always conduct compatibility and challenge testing.

Q3: What is the shelf life and are there any storage or stability concerns?

A: Shelf life is 24 months in original sealed packaging. Store in a cool, dry, well-ventilated area away from direct sunlight and high temperatures above 40°C. DMDM Hydantoin is stable under normal storage conditions but may gradually release more formaldehyde at elevated temperatures over extended periods. It is compatible with most cosmetic ingredients but should be tested for compatibility with very strong reducing agents. Always conduct stability and preservative efficacy challenge testing in your specific formulation to ensure shelf life performance and label compliance for formaldehyde content.

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