Hyaluronic acid - Moisturizing Active Ingredient in the Skincare Industry
Product Name: Hyaluronic Acid (as Sodium Hyaluronate)
INCI Name: Sodium Hyaluronate, Hyaluronic Acid
CAS Number: 9067-32-7 (Sodium Hyaluronate), 9004-61-9 (Hyaluronic Acid)
EINECS Number: 232-678-0
Available Molecular Weights:
<!--[if !supportLists]-->• <!--[endif]-->Ultra-Low MW: 3,000 - 10,000 Da (Oligo HA, Deep Penetration)
<!--[if !supportLists]-->• <!--[endif]-->Low MW: 10,000 - 100,000 Da (Epidermal Layer)
<!--[if !supportLists]-->• <!--[endif]-->Medium MW: 100,000 - 500,000 Da (Mid-Epidermal)
High MW: 800,000 - 1,500,000 Da (Surface Film-Forming)
Purity: ≥99.0% (Cosmetic Grade)
Appearance: White to off-white fibrous or crystalline powder
Molecular Formula: (C₁₄H₂₀NNaO₁₁)ₙ
Monomer Molecular Weight: 403.31 g/mol
Minimum Order Quantity (MOQ): 100g (Sample), 1kg (Bulk)
Packaging: 100g/500g foil bag, 1kg aluminum bottle, 25kg fiber drum
Solubility: Freely soluble in water; insoluble in ethanol, oils, organic solvents
pH Value (0.1% Solution): 5.5 - 7.5
Viscosity (0.1% Solution, 25°C): Varies by MW: 5 - 2000 mPa·s
Recommended Usage Level: 0.05 - 1.0% (typical: 0.1 - 0.3%)
Water Binding Capacity: Up to 1000 times its own weight in water
Effective pH Range: 4.0 - 8.5 (stable across full cosmetic pH range)
Applications: All skincare, serums, creams, masks, hair care, eye care, body care
Shelf Life: 24 months under cool, dry, sealed storage
Hyaluronic acid - Moisturizing Active Ingredient in the Skincare Industry（CAS 9067-32-7）
Hyaluronic Acid (HA), universally known as the "gold standard" moisturizing ingredient, is a naturally occurring glycosaminoglycan found abundantly in human skin, connective tissue, and synovial fluid. Commercial cosmetic grade HA is produced via advanced microbial fermentation (Streptococcus zooepidemicus), delivering consistent, animal-free, highly pure Sodium Hyaluronate - the salt form universally used in cosmetics.
What makes HA revolutionary is its molecular weight effect - different chain lengths deliver entirely distinct skin benefits:
• High MW (>800 kDa): Forms a breathable, protective moisture film on the skin surface, instantly plumping and smoothing fine lines
• Medium MW (100-500 kDa): Penetrates the epidermal layers, providing sustained mid-layer hydration
• Low MW (10-100 kDa): Reaches deeper epidermal layers, supporting skin barrier function
• Ultra-Low MW (<10 kDa): Penetrates to the dermal layer, delivering deep, long-lasting hydration and supporting collagen environment
With its legendary ability to bind 1000 times its weight in water, Hyaluronic Acid is the single most effective humectant in cosmetics. It is biocompatible, non-irritating, non-sensitizing, and suitable for every skin type - including sensitive, acne-prone, and compromised skin. It is the foundational active in virtually all premium moisturizing, anti-aging, and hydrating formulations worldwide.
Our cosmetic grade Hyaluronic Acid is available in all standard molecular weight fractions, as well as custom-blended multi-molecular weight HA systems for complete layer-by-layer skin hydration.
Key Benefits
✅ Legendary Hydration Power - Binds 1000x its weight in water; industry's most potent humectant
✅ Multi-Molecular Weight System - 4 MW fractions deliver layer-by-layer complete skin hydration
✅ Instant Plumping Effect - Visibly reduces fine lines and wrinkles within minutes of application
✅ All Skin Types - Suitable for sensitive, dry, oily, acne-prone, and compromised skin
✅ Barrier Repair Support - Strengthens skin's natural moisture barrier function
✅ Skin Soothing - Calms and reduces redness; ideal for post-procedure and sensitive skin
✅ Texture Enhancement - Improves product feel, slip, and luxurious sensory experience
✅ Long-Lasting Moisture - Provides sustained hydration for 24+ hours
✅ Globally Approved - No regulatory restrictions in any major cosmetic market
✅ Synergistic Active - Enhances efficacy of peptides, vitamins, and other skincare actives
Applications
Premium Skincare (Primary):
• Hydrating serums and essences: 0.1-0.5% multi-MW blend
• Anti-aging creams and lotions: 0.1-0.3% medium + high MW
• Eye creams and eye serums: 0.1-0.2% low + medium MW
• Facial masks (sheet, wash-off, sleeping): 0.05-0.3% all MW types
Specialized Skincare:
• Sensitive skin care and post-procedure products
• Acne care and oil-free moisturizers
• Barrier repair and ceramide formulations
• Sunscreens and after-sun products
Hair & Body Care:
• Premium shampoos and conditioners: 0.05-0.1%
• Body lotions and moisturizers
• Hand creams and cuticle treatments
• Scalp care and hair serums
Recommended HA Blends by Application:
• Basic hydration: 0.2% Medium MW (800 kDa)
• Premium serum blend: 0.1% High MW + 0.1% Low MW + 0.05% Ultra-Low MW
• Anti-aging formula: 0.15% Medium MW + 0.1% Low MW
• Sensitive skin: 0.15% High MW only (gentle surface hydration)
Important: Always dissolve HA powder in water first with high-shear mixing. Pre-hydration recommended for best results.
Certificate of Analysis (COA)
Item | Specification | Test Result |
Product Identification | ||
Product Name | Sodium Hyaluronate | Sodium Hyaluronate |
Molecular Weight | 800,000 - 1,200,000 Da | 986,000 Da |
Grade | Premium Cosmetic Grade | Premium Cosmetic Grade |
Quality Parameters | ||
Appearance | White fibrous powder | White fibrous powder |
Assay | ≥99.0% | 99.68% |
Loss on Drying | ≤10.0% | 6.82% |
pH (0.1% Solution) | 5.5 - 7.5 | 6.8 |
Viscosity (0.1% Solution) | 100 - 300 mPa·s | 186 mPa·s |
Glucuronic Acid | ≥44.0% | 45.3% |
Protein Content | ≤0.1% | <0.05% |
Purity & Safety | ||
Endotoxin | ≤0.05 EU/mg | <0.03 EU/mg |
Lead (Pb) | ≤2 ppm | <0.5 ppm |
Arsenic (As) | ≤2 ppm | <0.5 ppm |
Mercury (Hg) | ≤0.1 ppm | <0.05 ppm |
Microbiological Test | ||
Total Aerobic Count | ≤100 CFU/g | <10 CFU/g |
Yeast & Mold | ≤10 CFU/g | <10 CFU/g |
Conclusion | —— | PASSED |
Frequently Asked Questions (FAQ) & Document Request Frequently Asked Questions (FAQ) & Document Request
Q1: Why is molecular weight so important for Hyaluronic Acid?
A: Molecular weight determines penetration depth and function:
• >1,000 kDa: Stays on skin surface → forms protective film, instant plumping
• 100-500 kDa: Epidermal layer → mid-level hydration, texture improvement
• 10-100 kDa: Deep epidermis → barrier support, sustained hydration
• <10 kDa: Dermal layer → deep hydration, anti-aging support
Most premium formulations blend 2-4 MW fractions for complete layer-by-layer hydration.
Q2: What is the correct method to dissolve HA powder?
A: Critical for success:
1. Add HA powder SLOWLY to vigorously stirring water (not other ingredients)
2. Use high-shear mixing if available
3. Allow 30-60 minutes for complete hydration (hydrate overnight for best results)
4. Never dump powder all at once - causes clumping ("fish eyes")
5. Always dissolve HA first before adding other ingredients
Pre-made 1% stock solutions are also available for convenience.
Q3: Is Hyaluronic Acid safe for sensitive skin?
A: Exceptionally safe. HA is naturally present in human skin - it is 100% biocompatible, non-irritating, non-comedogenic, and non-sensitizing. It is actually recommended for sensitive, rosacea-prone, and post-procedure skin because of its soothing and barrier-supporting properties. It has one of the lowest irritation profiles of any cosmetic active.
Q4: Can HA be used with other active ingredients?
A: Excellent compatibility. HA is compatible with virtually all cosmetic ingredients including:
• Peptides, retinol, vitamin C, niacinamide
• AHAs/BHAs, ceramides, squalane
• All preservative systems
It actually ENHANCES the efficacy of other actives by improving skin hydration and barrier function, improving active penetration.
Q5: What are proper storage conditions?
A: HA powder is hygroscopic (absorbs moisture from air). Store in tightly sealed containers in a cool, dry place (below 25°C recommended). Avoid exposure to high humidity. Once dissolved in solution, preserve as with any aqueous cosmetic product. Shelf life of dry powder is 24 months from manufacture.
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