L-α-Glycerophosphocholine(CAS 28319-77-9)
Product Name: L-α-Glycerophosphocholine
Abbreviation: GPC
INCI Name: Glycerophosphocholine
CAS No.: 28319-77-9
Grade: Cosmetic Premium Grade (High-Purity Cell-level Skincare Special)
Purity: ≥99.0%
Appearance: White Fine Crystalline Powder, Uniform Fineness, No Caking, Odorless, Pure Texture
Molecular Formula: C₈H₂₀NO₆P
Molecular Weight: 257.22
MOQ (Minimum Order Quantity): 25KG
Solubility: Excellent water solubility, completely soluble in room-temperature pure water, clear and transparent solution; stable compatibility with humectants, peptides, antioxidants and various water-based and emulsion cosmetic systems, no precipitation, delamination or discoloration
Core Efficacy: Deep skin hydration, repair skin cell damage, promote phospholipid synthesis, strengthen cell membrane stability, anti-oxidation anti-aging, brighten dull skin, improve skin elasticity and fineness
Key Characteristics: Natural cell phospholipid active ingredient, cell-level skin repair mechanism, dual efficacy of moisturizing and anti-aging, mild non-irritating, high activity with low dosage, wide pH adaptability, stable formula performance, suitable for high-end delicate skincare formulas
Storage Condition: Sealed and stored in dry, cool and ventilated warehouse, avoid high temperature, humidity and strong light exposure; keep tightly sealed after opening to prevent moisture absorption and activity attenuation
Shelf Life: 24 Months
Application: Widely used in moisturizing essence, anti-aging face cream, repair lotion, brightening mask, delicate skincare and cell-level repair functional cosmetic formulas
L-α-Glycerophosphocholine, Cosmetic Grade GPC, Skin Cell Repair, Deep Hydration, Anti-aging, Skin Brightening, Moisturizing Skincare Raw Material
L-α-Glycerophosphocholine(CAS 28319-77-9)
Cosmetic Grade L-α-Glycerophosphocholine is a high-purity natural cell phospholipid active ingredient, which exists in human skin tissues naturally. As a core precursor of skin phospholipid synthesis, it participates in the construction of skin cell membrane structure and cell metabolism cycle, different from traditional superficial moisturizing and anti-aging ingredients.
GPC can efficiently penetrate the skin epidermal layer, supplement the missing glycerophosphocholine in aging skin, promote the synthesis of lecithin and phospholipids, repair damaged and incomplete cell membranes, enhance cell activity and stability, and fundamentally improve skin dryness, sagging and dullness caused by cell aging.
It has excellent deep moisturizing performance, which can lock skin moisture for a long time, relieve dry tightness and fine dry lines. Meanwhile, it can scavenge skin free radicals, inhibit oxidative damage of cells, delay skin aging process, improve rough and dull skin texture, and restore skin delicate and translucent luster.
With pure natural skin-friendly properties, non-irritating and non-sensitizing, wide pH adaptation range and excellent formula compatibility, it does not affect the color, fragrance and viscosity of finished products. It is an indispensable core raw material for high-end cell-level repair, moisturizing and anti-aging skincare products.



Key Benefits
•Cell-level Repair, Fundamental Anti-aging: Natural skin homologous phospholipid component, repair damaged cell membranes, activate skin cell metabolism, delay cell aging, and solve aging problems from the source, more thorough than traditional skincare ingredients.
•Deep Long-lasting Hydration, Improve Dry Skin: Different from superficial water replenishment, it builds intracellular water-locking system, long-term moisturizing, relieves dry tightness, dry lines and peeling, and keeps skin moist and tender all day.
•Promote Phospholipid Synthesis, Firm Skin Texture: Supplement skin core lipid nutrients, accelerate phospholipid regeneration, enhance skin tissue density and elasticity, improve sagging and loose skin, and refine skin texture.
•Anti-oxidation & Brighten Dull Complexion: Scavenge skin free radicals, resist cellular oxidative aging, improve tired dull and yellowish skin, uniform skin tone, and restore skin translucent luster.
•Natural Homologous & Ultra-mild Safety: Human skin endogenous active ingredient, high skin affinity, non-irritating, non-sensitizing, no burden on skin, suitable for sensitive skin and fragile delicate skin maintenance.
•High Formula Stability & Easy Mass Production: Fully water-soluble, stable in full pH range, compatible with all mainstream skincare active ingredients, no discoloration and no inactivation, low dosage and high efficiency, convenient for industrial production.
Applications
• High-end Moisturizing & Repair Essence: Core active ingredient of deep moisturizing essence and cell repair stock solution, realize intracellular water locking and cell damage repair, and improve dry and aging skin fundamentally.
• Anti-aging Firming Cream & Lotion: Added in anti-aging face cream, firming lotion and nourishing skincare products, enhance skin elasticity, improve fine lines and sagging, and delay skin aging.
• Sensitive & Fragile Skin Care Products: Suitable for sensitive skin soothing and repair formulas, strengthen cell membrane stability, improve skin tolerance, and repair fragile sub-health skin state.
• Brightening & Translucent Skin Mask: Applied in moisturizing brightening mask and repair mask, quickly improve dry dull skin, replenish skin nutrition, and present delicate and translucent skin texture.
• Daily Delicate Skincare Series: Widely used in daily moisturizing, anti-oxidation and anti-initial aging skincare products, maintain skin cell vitality, and keep skin young and tender for a long time.
• High-end Cell-level Custom Formula: As a homologous cell active ingredient, build high-end luxury delicate skincare system, improve product efficacy barrier and market competitiveness.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | L-α-Glycerophosphocholine | Compliant |
CAS No. | 28319-77-9 | Compliant |
Appearance | White Fine Crystalline Powder | Compliant |
Purity (HPLC) | ≥99.0% | 99.55% |
Loss on Drying | ≤0.5% | 0.10% |
Residue on Ignition | ≤0.1% | 0.03% |
Heavy Metal (Pb) | ≤1ppm | 0.2ppm |
Arsenic (As) | ≤0.5ppm | 0.1ppm |
Total Bacteria | ≤100CFU/g | Qualified |
Pathogenic Bacteria | Negative | Negative |
Conclusion | Conforms to cosmetic grade quality standard | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What is the MOQ of L-α-Glycerophosphocholine?
A1: The standard MOQ is 25KG, and sample orders are supported for formula testing and skincare efficacy trial production.
• Q2: What certification documents can be provided?
A2: Complete COA, MSDS, heavy metal and microbial test reports and full set of customs clearance documents are available to support export declaration and cosmetic product filing.
• Q3: What is the recommended dosage in cosmetic formulas?
A3: Conventional addition dosage is 0.1%-0.3% for daily lotion and cream; 0.3%-0.8% for repair essence and brightening mask, adjustable according to moisturizing and anti-aging efficacy requirements.
• Q4: What is the core advantage of GPC compared with ordinary moisturizing ingredients?
A4: Ordinary moisturizing ingredients only replenish water superficially, while GPC is a cell-level active ingredient. It can repair cell membranes, promote lipid synthesis, and realize integrated effects of moisturizing, repair and anti-aging, with more durable and deeper skincare effect.
• Q5: Is GPC suitable for sensitive skin formulas?
A5: Yes, GPC is a skin endogenous homologous ingredient with ultra-mild properties, no irritation and no sensitization. It can strengthen skin barrier while moisturizing, which is very suitable for sensitive and fragile skin skincare products.
• Q6: Can GPC be compounded with other skincare ingredients?
A6: It has excellent synergistic effect with hyaluronic acid, peptides, VC derivatives and ceramides, forming a multi-dimensional skincare system of moisturizing, repair, anti-oxidation and anti-aging to double the product efficacy.
• Q7: Do you support stable large-batch supply all year round?
A7: Standardized production lines ensure sufficient inventory and stable annual output, supporting long-term cooperative orders and customized formula matching services.
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