Cosmetic Grade Aminoethylphosphinic Acid-CAS 74333-44-1
Product Name: Aminoethylphosphinic Acid
Chemical Name: (1-Aminoethyl)phosphinic Acid / 1-Aminoethylphosphonous Acid
Alternative Names: AEP, 1-Aminoethylphosphinic Acid, Brillian-MB288, Cosroma® AEP, Aobaiting
INCI Name: AMINOETHYLPHOSPHINIC ACID
CAS No.: 74333-44-1
Molecular Formula: C₂H₈NO₂P
Molecular Weight: 109.06 g/mol
Chemical Class: Organic phosphorus compound / Phosphinic acid derivative
Purity: ≥99.0% (HPLC), Cosmetic Grade
Also Available: 98% purity grade
Appearance: White to Off-White Crystalline Powder
Odor: Odorless or slight characteristic odor
Solubility: Freely soluble in water, soluble in polar solvents, slightly soluble in ethanol
pH Value (1% Aqueous Solution): 2.0 - 3.5
Melting Point: ~230-240°C (decomposition)
Loss on Drying: ≤0.5%
Residue on Ignition: ≤0.2%
Heavy Metals (as Pb): ≤10 ppm
Arsenic (As): ≤2 ppm
Total Plate Count: ≤100 CFU/g
Yeast & Mold: ≤10 CFU/g
Key Characteristics: High-purity water-soluble skin brightening active, inhibits dopachrome tautomerase (TRP-2), regulates melanin synthesis, antioxidant and chelating properties, improves skin microcirculation, activates metabolism, excellent formulation stability, high safety profile, suitable for all skin types
Storage Condition: Sealed, dry, cool and well-ventilated place, protect from light and moisture, store at room temperature
Shelf Life: 24 Months under proper storage conditions
MOQ (Minimum Order Quantity): 100g (sample), 1KG (standard)
Source / Origin: Synthetic production, high-purity organic phosphorus compound
Application: Skin brightening and whitening active, antioxidant, chelating agent, skin conditioning agent; used in whitening serums, brightening creams, anti-spot products, anti-aging formulations, antioxidant skincare, and daily skin conditioning products
Aminoethylphosphinic Acid, AEP, Cosmetic Grade Aminoethylphosphinic Acid, Skin Brightening Agent, Antioxidant Active, Melanin Inhibitor, Skin Conditioning Agent, Chelating Agent
Cosmetic Grade Aminoethylphosphinic Acid-CAS 74333-44-1
Cosmetic Grade Aminoethylphosphinic Acid (AEP) is a high-purity organic phosphorus compound specifically developed for advanced skincare formulations. As a specialized skin brightening active, it works by inhibiting dopachrome tautomerase (TRP-2), a key enzyme in the melanin synthesis pathway, effectively regulating melanin production without compromising skin barrier integrity. This unique mechanism helps reduce hyperpigmentation, even out skin tone, and promote a brighter, more radiant complexion.
Beyond its skin brightening benefits, Aminoethylphosphinic Acid exhibits excellent antioxidant and chelating properties. It binds to metal ions that can trigger oxidation reactions, enhancing formulation stability and extending product shelf life. It also helps improve skin microcirculation and activates cellular metabolism, contributing to overall skin health and vitality. With high water solubility, excellent formulation compatibility, and an exceptional safety profile, Aminoethylphosphinic Acid is suitable for a wide range of skincare products including whitening serums, brightening creams, anti-spot treatments, anti-aging formulations, and daily skin care products. Fully compliant with global cosmetic regulations, it is a premium multi-functional active ingredient for modern high-performance skincare.
Key Benefits
• Effective Skin Brightening: Inhibits dopachrome tautomerase (TRP-2), regulates melanin synthesis, reduces hyperpigmentation and evens skin tone.
• Unique Mechanism of Action: Targets TRP-2 enzyme in melanin pathway, different from traditional tyrosinase inhibitors, offering complementary brightening effects.
• Powerful Antioxidant: Scavenges free radicals and protects skin from oxidative stress and environmental damage.
• Metal Chelating Activity: Binds transition metal ions, prevents formulation oxidation, enhances product stability and shelf life.
• Improves Microcirculation: Enhances skin blood circulation, promotes nutrient delivery, and supports healthy skin metabolism.
• Activates Cellular Metabolism: Boosts skin cell vitality, promotes skin renewal and overall skin health.
• High Water Solubility: Freely soluble in water, easy to incorporate into aqueous formulations without solubility issues.
• Excellent Formulation Compatibility: Compatible with most cosmetic ingredients including other whitening actives, antioxidants, and humectants.
• High Safety Profile: Excellent skin tolerance, low irritation potential, suitable for all skin types including sensitive skin.
• Multi-Functional Active: Skin brightening + antioxidant + chelating + skin conditioning + anti-aging, five benefits in one ingredient.
• Stable & Long-Lasting: Excellent thermal and pH stability, maintains efficacy throughout product shelf life.
• Premium Whitening Ingredient: High-purity active, premium positioning for high-end brightening and anti-aging skincare formulations.
Applications
• Whitening & Brightening Serums: Primary brightening active in whitening serums, essence liquids and ampoules for reducing dark spots and evening skin tone.
• Brightening Creams & Lotions: Incorporated into day creams, night creams and brightening lotions for sustained skin brightening and overall complexion improvement.
• Anti-Spot & Hyperpigmentation Treatments: Used in spot correctors, dark spot treatments and melasma care products to target localized hyperpigmentation.
• Antioxidant Skincare: Added to antioxidant serums, day creams and protective products for free radical scavenging and environmental protection.
• Anti-Aging & Rejuvenation Products: Used in anti-aging serums and creams to improve skin elasticity, firmness and overall skin vitality.
• Daily Skin Conditioning: Incorporated into toners, essences and daily moisturizers for general skin conditioning and health maintenance.
• Eye Care Products: Suitable for eye creams and eye serums to brighten under-eye area and reduce dark circles.
• Body Care: Added to body lotions, body serums and brightening body washes for overall body skin brightening.
• Custom Brightening Systems: Supports customized development of combined brightening systems with other whitening actives like niacinamide, alpha arbutin, tranexamic acid and vitamin C derivatives.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | Aminoethylphosphinic Acid | Compliant |
INCI Name | AMINOETHYLPHOSPHINIC ACID | Compliant |
CAS No. | 74333-44-1 | Compliant |
Appearance | White to Off-White Crystalline Powder | Compliant |
Odor | Odorless or slight characteristic | Compliant |
Purity (Assay by HPLC) | ≥99.0% | 99.42% |
Molecular Formula | C₂H₈NO₂P | Compliant |
Molecular Weight | 109.06 g/mol | Compliant |
Identification (IR) | Conforms to reference standard | Compliant |
pH Value (1% Solution) | 2.0 - 3.5 | 2.85 |
Loss on Drying | ≤0.5% | 0.18% |
Residue on Ignition | ≤0.2% | 0.08% |
Melting Point | ~230-240°C (decomposition) | 235°C (decomp.) |
Solubility in Water | Clear solution (10% solution) | Clear, fully soluble |
Heavy Metals (as Pb) | ≤10 ppm | <5 ppm |
Arsenic (As) | ≤2 ppm | <0.5 ppm |
Lead (Pb) | ≤2 ppm | <0.3 ppm |
Mercury (Hg) | ≤1 ppm | <0.1 ppm |
Cadmium (Cd) | ≤1 ppm | <0.1 ppm |
Phosphorus Content | 27.5 - 29.0% | 28.3% |
Total Aerobic Count | ≤100 CFU/g | <10 CFU/g |
Yeast & Mold | ≤10 CFU/g | <1 CFU/g |
E. coli | Negative | Negative |
Salmonella | Negative | Negative |
Staphylococcus aureus | Negative | Negative |
Pseudomonas aeruginosa | Negative | Negative |
Candida albicans | Negative | Negative |
Conclusion | Conforms to cosmetic grade quality standard | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What is the MOQ of cosmetic grade Aminoethylphosphinic Acid?
A1: The standard MOQ is 1KG, and 100g sample orders are supported for quality inspection and formulation testing.
• Q2: What purity grades are available and which one should I choose?
A2: We offer 98% and 99% purity grades. 99% is the standard cosmetic grade and recommended for most skincare applications; 98% is more cost-effective for price-sensitive formulations.
• Q3: Is Aminoethylphosphinic Acid compliant with international cosmetic regulations?
A3: Yes, it is listed in China IECIC and EU CosIng. It is a globally accepted cosmetic ingredient with an excellent safety profile and no specific use concentration restrictions.
• Q4: What is the recommended usage level in cosmetic formulations?
A4: Typical use level is 0.5-2.0% depending on product type: 0.5-1% for daily brightening products, 1-2% for intensive whitening and anti-spot treatments. It can be used alone or combined with other whitening actives.
• Q5: How does Aminoethylphosphinic Acid work for skin brightening compared to other whitening ingredients?
A5: Unlike traditional tyrosinase inhibitors (like arbutin or kojic acid), AEP targets dopachrome tautomerase (TRP-2), a different enzyme in the melanin synthesis pathway. This makes it highly complementary to other whitening actives - combining AEP with niacinamide, arbutin or vitamin C creates a multi-pathway brightening system with enhanced efficacy.
• Q6: What formulation considerations should I be aware of?
A6: AEP is highly water-soluble and stable across a wide pH range. It is compatible with most cosmetic ingredients. As an acidic ingredient, it may lower formulation pH slightly - adjust accordingly if needed. It works well in both cold-process and hot-process formulations.
• Q7: Can it be combined with other whitening and antioxidant ingredients?
A7: Absolutely - AEP is highly synergistic with other actives. Popular combinations include: AEP + Niacinamide + Alpha Arbutin (multi-pathway whitening), AEP + Vitamin C derivatives + Ferulic Acid (antioxidant brightening), AEP + Tranexamic Acid (anti-spot and anti-inflammatory).
• Q8: Do you support long-term stable large-batch supply?
A8: Yes, our production facility has sufficient capacity to ensure sustainable and stable bulk supply all year round, with consistent quality across batches. We also offer custom packaging and specification options for bulk customers.
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