Polylysine Hydrochloride Natural Biological Preservative

Product Name: Polylysine Hydrochloride

Common Name: Polylysine Hydrochloride

INCI Name: Polylysine Hydrochloride

CAS Number: 25104-18-1

Source: Microbial fermentation from Streptomyces diastatochromogenes

Molecular Formula: (C₆H₁₂N₂O)n·HCl

Appearance: White to off-white crystalline powder, odorless, non-hygroscopic

Purity: ≥99.0% (HPLC), Food & Cosmetic Dual Grade

Solubility: Freely soluble in water, soluble in propylene glycol, insoluble in oil phase and organic solvents

Effective pH Range: 2.0–9.0, ultra-wide pH stability

Heat Resistance: Stable bacteriostatic activity up to 120℃, suitable for high-temperature sterilization processes

Max Legal Dosage (Cosmetic): 0.1% globally compliant

Grade: Food Grade / Cosmetic Grade, Clean Beauty Certified, Zero Irritation Grade

MOQ: 100g / 1KG / 25KG Drum

Shelf Life: 24 months (sealed, light-proof, cool and dry storage below 25℃)

Key Features: Natural fermentation source, food-grade safety, broad-spectrum bacteriostasis, high temperature resistant, no drug resistance, fully biodegradable

Polylysine Hydrochloride, Polylysine Hydrochloride, Natural Biological Preservative, Food Grade Cosmetic Raw Material, Non-irritating Preservative, High Temperature Resistant, Wide pH Bacteriostatic, Clean Beauty Preservative, Baby Safe Cosmetic Additive


Polylysine Hydrochloride-CAS 25104-18-1

  • Polylysine Hydrochloride is a high-safe natural biological preservative fermented and purified by microbial technology.

  • Different from traditional chemical preservatives, it belongs to cationic polypeptide active substance with food-grade safety attributes.

  • It efficiently inhibits gram-positive bacteria, gram-negative bacteria, molds and yeasts, solving product deterioration, mildew and odor problems from the source.

  • With ultra-wide pH adaptability and excellent thermal stability, it maintains stable efficacy in acidic, neutral and weak alkaline systems, and withstands conventional cosmetic high-temperature production processes.

  • The raw material is non-irritating, non-sensitizing, non-toxic and fully biodegradable, leaving no chemical residues.

  • It is the core preferred preservative for high-end clean beauty, maternal and infant care, sensitive skin and zero-add mild cosmetic formulas, compliant with China, EU and global cosmetic regulations.

Polylysine Hydrochloride

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Key Benefits

Food-grade Safety & Zero Irritation: Natural microbial fermentation source, food-additive grade safety standard, non-toxic, non-sensitizing, no skin and mucosal irritation, specially suitable for pregnant women, infants and sensitive fragile skin.

Full Broad-spectrum Bacteriostasis: Effectively suppresses bacteria, molds and yeasts, covers all common spoilage microorganisms in cosmetics, comprehensively guarantees formula long-term stability.

Ultra-wide Environmental Adaptability: Stable and effective in pH 2.0–9.0 full range, resistant to high temperature processing, no activity loss in high-temperature sterilization and emulsification processes.

No Drug Resistance & Green Degradation: Long-term use does not produce microbial drug resistance, fully biodegradable, green and environmentally friendly, no residual pollution, meets clean beauty green standards.

Excellent Formula Compatibility: Excellent water solubility, compatible with all conventional cosmetic raw materials and surfactant systems, no precipitation, discoloration or peculiar smell, does not affect product skin feel and transparency.

Low Dosage & High Stability: Low effective concentration, stable long-term efficacy, can be used alone or compounded to reduce overall preservative dosage and optimize formula safety.

Applications

Sensitive Skin Care Series: Soothing toner, moisturizing lotion, repair essence, sensitive skin barrier care products, zero-irritation daily skin care.

Maternal & Infant Care Series: Pregnant women skin care, baby shampoo and body wash, infant moisturizing cream, mild nursing formulas.

Clean & Zero-add Beauty Series: Pure plant formulas, zero chemical preservative addition schemes, green mild skin care products.

Water-based High-moisture Products: Hydrating spray, moisturizing water, water-soluble essence, transparent fresh skin care with high water content.

Food-contact Daily Chemicals: Hand sanitizer, fruit and vegetable cleaning lotion, skin care and cleaning products that can contact food.

Mild Functional Cosmetics: Acne-soothing skin care, oil-water balancing products, mild bacteriostatic and anti-inflammatory daily chemical formulas.

Certificate Of Analysis (COA)

Test Item

Standard Specification

Test Result

Product Name

ε-Polylysine Hydrochloride

Compliant

Appearance

White to Off-white Crystalline Powder

White Uniform Powder

Purity (HPLC)

≥99.0%

99.6%

Loss on Drying

≤5.0%

2.08%

Residue on Ignition

≤1.0%

0.40%

pH (1% Aqueous Solution)

5.0–7.0

6.2

Heavy Metal (Pb)

≤1ppm

<0.5ppm

Arsenic (As)

≤0.2ppm

Qualified

Total Microorganism

≤100CFU/g

Qualified

Conclusion

Meets food & cosmetic grade standards

Qualified


Frequently Asked Questions (FAQ)

Q1: What makes Polylysine Hydrochloride different from traditional preservatives? 

A1: It is a natural fermented polypeptide preservative with food-grade safety, zero irritation, high temperature resistance and wide pH efficacy. No chemical residues and no drug resistance, ideal for clean beauty and maternal-infant formulas.

Q2: What is the compliant dosage for cosmetics? 

A2: Global maximum legal limit 0.1%. Recommended dosage: conventional skin care 0.02%–0.05%, high-water formulas 0.05%–0.08%, maternal & infant products 0.02%–0.04%.

Q3: How to dissolve and add correctly? 

A3: Water-phase addition, freely soluble in normal-temperature water, stir evenly without heating. Simple operation, no precipitation or stratification.

Q4: What ingredients are suitable for compounding? 

A4: Synergizes well with phenoxyethanol, ethylhexylglycerin, plant preservatives and polyols, enhances antiseptic efficiency and reduces single-preservative dosage.

Q5: Is it safe for sensitive skin and babies? 

A5: Food-grade non-toxic raw material, non-irritating and non-sensitizing, officially approved for sensitive skin and infant mild care products.

Q6: Does high temperature and pH fluctuation affect efficacy? 

A6: Stable at 120℃ high temperature and pH 2.0–9.0 range, no efficacy attenuation during cosmetic emulsification and sterilization process.

Contact Us

 💌 Contact us today for technical data, formulation guidance, and competitive pricing! E-mail: 

sales10@huilinbio-tech.com



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